Journal: Pharmaceutics

Article Title: Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals

doi: 10.3390/pharmaceutics12010050

Figure Lengend Snippet: Fluorescence-based analytical platforms for cell analysis with metallic nanomaterials.

Article Snippet: Solution-based metallic nanoparticles , Au nanoparticle, Quantum dot , Fluorescence resonance energy transfer (FRET), Dequenching-Quenching , miR-21 , Differentiation between cancer cells and normal cells miRNA detection with spatiotemporal control in living cells , [ , ] .

Techniques: Fluorescence, Cell Analysis, Förster Resonance Energy Transfer, Control, Amplification, Microarray, Membrane

Journal: Pharmaceutics

Article Title: Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals

doi: 10.3390/pharmaceutics12010050

Figure Lengend Snippet: Fluorescence-based intracellular and extracellular analysis using metallic nanomaterials. ( a ) Au nanoparticle-quantum dots (QDs) nanoassembly for catalytic intracellular miRNA sensing with fuel DNA strands. Reproduced with permission . Copyright 2015, ACS Publications. ( b ) “OFF-Enhanced ON” fluorescent switching system for the specific detection of miRNAs in intact cancer cells. Reproduced with permission . Copyright 2018, ACS Publications. ( c ) Plasmonic gold chip with nanostructures for the metal enhanced fluorescence-induced immunofluorescence detection. Reproduced with permission . Copyright 2016, WILEY-VCH. ( d ) Au plasmonic chip consisted of two-dimensional periodic structure for the enhanced fluorescence effect. Reproduced with permission . Copyright 2016, ACS Publications.

Article Snippet: Solution-based metallic nanoparticles , Au nanoparticle, Quantum dot , Fluorescence resonance energy transfer (FRET), Dequenching-Quenching , miR-21 , Differentiation between cancer cells and normal cells miRNA detection with spatiotemporal control in living cells , [ , ] .

Techniques: Fluorescence, Immunofluorescence

Journal: Pharmaceutics

Article Title: Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals

doi: 10.3390/pharmaceutics12010050

Figure Lengend Snippet: LSPR-based analytical platforms for the cell analysis with the metallic nanomaterials.

Article Snippet: Solution-based metallic nanoparticles , Au nanoparticle, Quantum dot , Fluorescence resonance energy transfer (FRET), Dequenching-Quenching , miR-21 , Differentiation between cancer cells and normal cells miRNA detection with spatiotemporal control in living cells , [ , ] .

Techniques: Cell Analysis, Activity Assay, Imaging, Glycoproteomics, In Situ, Expressing, Fluorescence

Journal: Pharmaceutics

Article Title: Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals

doi: 10.3390/pharmaceutics12010050

Figure Lengend Snippet: Localized surface plasmon resonance (LSPR)-based intracellular and extracellular analysis using metallic nanomaterials. ( a ) Survivin mRNA analysis using nanoprobes, composed of molecular beacon, small and large Au nanoparticle. Reproduced with permission . Copyright 2016, Royal Society of Chemistry. ( b ) The high-throughput method for studying the resonance scattering light of single plasmonic nanoparticles in a dark-field image for intracellular analysis. Reproduced with permission . Copyright 2015, Ivyspring International Publisher. ( c ) Adipose-tissue-on-chip sensing platform for an in situ multiplexed analysis of adipose tissue inflammation by changing LSPR property of the Au nanorod. Reproduced with permission . Copyright 2018, Royal Society of Chemistry. ( d ) Cell analysis by total internal reflection fluorescence (TIRF) microscope system on Au nanosheets. Reproduced with permission . Copyright 2017, PLOS.

Article Snippet: Solution-based metallic nanoparticles , Au nanoparticle, Quantum dot , Fluorescence resonance energy transfer (FRET), Dequenching-Quenching , miR-21 , Differentiation between cancer cells and normal cells miRNA detection with spatiotemporal control in living cells , [ , ] .

Techniques: SPR Assay, High Throughput Screening Assay, In Situ, Cell Analysis, Fluorescence, Microscopy

Journal: Pharmaceutics

Article Title: Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals

doi: 10.3390/pharmaceutics12010050

Figure Lengend Snippet: Surface-enhanced Raman spectroscopy (SERS)-based analytical platforms for the cell analysis with the metallic nanomaterials.

Article Snippet: Solution-based metallic nanoparticles , Au nanoparticle, Quantum dot , Fluorescence resonance energy transfer (FRET), Dequenching-Quenching , miR-21 , Differentiation between cancer cells and normal cells miRNA detection with spatiotemporal control in living cells , [ , ] .

Techniques: Raman Spectroscopy, Cell Analysis, In Situ, Activity Assay, Imaging, Marker, Expressing

Journal: Pharmaceutics

Article Title: Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals

doi: 10.3390/pharmaceutics12010050

Figure Lengend Snippet: SERS-based intracellular analysis using metallic nanoparticles. ( a ) Synthesis of Au nanoparticle in the HeLa cells after incubation with a gold chloride solution and they were measured by the SERS analytical method. Reproduced with permission . Copyright 2013, WILEY-VCH. ( b ) Biohybrid Au nanoparticles and time-dependent monitoring of the nanoparticle’s specific targeting, cellular uptake, release of doxorubicin in the cancer cells by glutathione. Reproduced with permission . Copyright 2015, Elsevier. ( c ) Ag-graphene oxide nanoparticles for the excellent SERS sensing capability biocompatible nanoprobes for intracellular biosensing of the releasing doxorubicin. Reproduced with permission . Copyright 2018, ACS Publications. ( d ) 4-aminothiophenol (ATP) modified-Au–Ag core-shell nanorods for the improvement of SERS effect and SERS tracking inside live cancer cells. Scale bar is 100 nm. Reproduced with permission . Copyright 2019, Elsevier.

Article Snippet: Solution-based metallic nanoparticles , Au nanoparticle, Quantum dot , Fluorescence resonance energy transfer (FRET), Dequenching-Quenching , miR-21 , Differentiation between cancer cells and normal cells miRNA detection with spatiotemporal control in living cells , [ , ] .

Techniques: Incubation, Modification